Journal: BMC neurology

Article Title: Intrathecal interleukin-6 levels are associated with progressive disease and clinical severity in multiple sclerosis.

doi: 10.1186/s12883-025-04145-0

Figure Lengend Snippet: Fig. 2 Ella vs. Planar Array. IL-6 levels in CSF were determined using the Ella® microfluidics assay, which correlates with the SiMOA® Planar Array results

Article Snippet: IL-6 was further quantified using Simple Plex Human NfL Cartridge with an Ella® automated immunoassay system (Catalog # SPCKB-PS-003028, Protein Simple, San Jose, CA, USA, Table 1).

Techniques:

Journal: BMC neurology

Article Title: Intrathecal interleukin-6 levels are associated with progressive disease and clinical severity in multiple sclerosis.

doi: 10.1186/s12883-025-04145-0

Figure Lengend Snippet: Fig. 3 Intrathecal IL-6 is increased in PPMS. IL-6 levels in CSF of HCs vs. RRMS and PPMS measured with Ella®. (A) IL-6 levels were significantly higher in PPMS vs. HCs (p = 0.0428). Statistical significance was determined using the Mann-Whitney test. * p < 0.5. (B) Receiver operating characteristic (ROC) analysis demonstrated the capacity of IL-6 levels to distinguish between RRMS and PPMS with an area under the curve (AUC) of 0.7060, and statistical significance (p = 0.0139)

Article Snippet: IL-6 was further quantified using Simple Plex Human NfL Cartridge with an Ella® automated immunoassay system (Catalog # SPCKB-PS-003028, Protein Simple, San Jose, CA, USA, Table 1).

Techniques: MANN-WHITNEY